Human neural stem cells transduced with IFN-beta and cytosine deaminase genes intensify bystander effect in experimental glioma. Wang3, Huong Pham3, Kristofer L. Immunization of mice by hollow mesoporous silica nanoparticles as carriers of porcine circovirus type 2 ORF2 protein.
Cationic particles were prepared by blending positively charged polymers with PLGA prior to the imprint lithography process.
To date, two kinds of eukaryocyte membrane coated particles have been investigated, cancer cell membrane-coated PLGA NPs and leukocyte membrane-coated nanoporous silicon particles[ 34].
Mokari T, Banin U. Then, agarose gel electrophoresis was used to verify the formation of nucleic acid nanogels. The authors showed that incorporating phosphotidylserine, a lipid more susceptible to macrophage recognition and capture, increased the lymph node accumulation by 3-fold. Exosomes for Drug Delivery Exosomes are with a nano-size structure which are stable in the circulation and can thus achieve a passive targeting via the enhanced permeation retention EPR effect[, ].
Despite the many examples of successful vaccines, many disease threats, such as human immunodeficiency virus HIVtuberculosis, dengue, and malaria, lack an effective prophylactic measure.
J Phys Chem C. Multifunctional theranostic red blood cells for magnetic-field-enhanced in vivo combination therapy of cancer. Tumor Cell-derived Microparticles Tumor cell-derived MPs were recently developed to deliver chemotherapeutic drugs[ 25 ].
The functionalization and bioconjugation chemistry for QDs is summarized in Figure 3. In the following sections, these two main applications of exosomes, immunomotherapy and drug delivery, were discussed. Proteomics, transcriptomics and lipidomics of exosomes and ectosomes. Virus surfaces display antigenic epitopes in an ordered and highly repetitive fashion, and the presentation of repetitively arranged and appropriately spaced antigens on the surface of virus or virus-like particles has been linked to enhanced immune responses [ ].
Gold nanoparticles As gold is chemically inert, gold nanoparticles AuNPs have been studied extensively for biomedical applications. Theranostic liposomes for cancer diagnosis and treatment: The size-dependent lymph node targeting was also observed in other solid particle platforms.
In particular, chitosan-based nanoparticles have been widely studied due to their biocompatibility, biodegradability, non-toxic nature and their ability to be easily modified into desired shapes and sizes [ 83 - 85 ]. The results revealed that both nanogels and magnetic nanogels seem to be a promising candidate to possess the toxic potential effect of free-doxorubicin at lower concentrations to improve the therapeutic efficiency of anticancer drug.
Poorly soluble anticancer drug, paclitaxel (PTX) and hydroxycamptothecin (HCPT), were used as model drugs and incorporated into nanogels. The results obtained from FT-IR spectroscopy confirmed that the drugs were molecularly dispersed in the nanogels.
Nanogels with a biomolecular coating (biocoating) were shown to be capable of triggered delivery of anticancer drug Doxorubicin. The biocoating was formed utilizing binding between glycogen and the tetra-functional lectin Concanavalin A, which can be triggered to disassemble (and release) upon.
Title:Supramolecular Self-Assembled Nanogels a New Platform for Anticancer Drug Delivery VOLUME: 23 ISSUE: 35 Author(s):Jaleh Varshosaz*, Somayeh Taymouri and Erfaneh Ghassami Affiliation:Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical.
Nanogels with a biomolecular coating (biocoating) were shown to be capable of triggered delivery of anticancer drug Doxorubicin.
The biocoating was formed utilizing binding between glycogen and. Oct 07, · Targeted drug delivery using multifunctional polymeric nanocarriers is a modern approach for cancer therapy. Our purpose was to prepare targeted nanogels for selective delivery of chemotherapeutic agent cisplatin to luteinizing hormone-releasing hormone (LHRH) receptor overexpressing tumor in vivo.Nanogels for anticancer drug delivery